Question: Please tell me we haven’t see the last of Penny on Grey’s Anatomy. She became my favorite this season.
Ausiello: Seeing as how she and Callie are sort of a package deal, I can confirm that we’ve seen the last of Penny. For now, anyway. Shonda Rhimes left the door wide open for Sara Ramirez to make the occasional guest appearance as Callie shuttles Sophia back and forth between New York and Seattle, and I suppose Penny — and her portrayer Samantha Sloyan — could tag along on one of those trips. I wouldn’t hold my breath, though.
Source: TV Line